منابع مشابه
The pulmonary macrophage.
An overview of the pulmonary macrophage is provided, with particular emphasis on the origin of this cell and the adaptive mechanisms whereby the macrophagic system is able to respond to increased inhalant loads of organic and inorganic pollutants. Evidence is presented which favors an hematopoietic origin for the alveolar macrophage with a monocytic transportation compartment in the blood and a...
متن کاملMacrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators in the pathogenesis of IPF was recently documented. This paper focuses on recent literature on p...
متن کاملHuman pulmonary macrophage tumor cell cytotoxicity.
In vivo animal studies support the concept that monocytes and macrophages are important in the immune surveillance of oncogenesis and in vitro activated murine macrophages are cytocidal for tumor cells. In this study. we examined human pulmonary macrophage and blood monocyte tumor cell cytotoxicity (a measure of cytostasis and cell kill) and cytocidal activity (cell kill). Three human tumor cel...
متن کاملHuman pulmonary macrophage-derived mucus secretagogue
Human pulmonary macrophages (PM) obtained from surgically removed human lung tissue released a factor after exposure to activated zymosan that caused cultured human airways to release increased amounts of radiolabeled mucous glycoproteins. The factor was released maximally after 4-8 h of zymosan exposure and caused a dose-related increase in glycoprotein release; it was termed macrophage-derive...
متن کاملToxicity of mycotoxins for the rat pulmonary macrophage in vitro.
The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macropha...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1976
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.761655